Mutations in HLA genes seem to play a crucial role in the pathogenesis of some cases (but not all), likewise silica, aromatic and chlorinated solvents, ketones, trichloroethylene, welding fumes and white spirits exposure seems to contribute to the condition in a small proportion of affected persons. Vitamin D is implicated in the pathophysiology of the disease. Ara patient information hydroxychloroquine Hypnozoites malaria chloroquine Chloroquine injection during pregnancy Chloroquine ic50 3d7 Nonsterodial anti-inflammatory drugs and hydroxychloroquine Plaquenil help both conditions. Most patients with pure schleroderma do not benefit from corticosteroids. Methotrexate, azathioprine, prednisone or cyclophosphamide help lupus and overlap syndromes, and perhaps scleroderma lung disease. This is a reivew of how effective Plaquenil hydroxychloroquine sulfate is for Systemic sclerosis scleroderma and for what kind of people. The study is created by eHealthMe from 11 Plaquenil users and is updated continuously. eHealthMe has been monitoring drugs since 2008. I may be wrong I often am! but I think there are more listed side effects for aspirin than there are for plaquenil; and by a very long shot, it would seem to be safer than steroids, especially for scleroderma patients. Basically, plaquenil's effect is to modulate the immune system, which is something that could be quite beneficial for some of us. Typical scleroderma is classically defined as symmetrical skin thickening, with about 70% of cases also presenting with Raynaud's phenomenon, nail-fold capillary changes and antinuclear antibodies. An inverse correlation between plasma levels of vitamin D and scleroderma severity has been noted and vitamin D is known to play a crucial role in regulating (usually suppressing) the actions of the immune system. Plaquenil scleraderma Scleroderma Definition, Types, Symptoms, Causes, and., How effective is Plaquenil for Systemic sclerosis. Chloroquine tablets to buy For severe or widespread morphea, your doctor may prescribe an immunosuppressive medication, such as oral methotrexate Trexall, corticosteroid pills or both. Or your doctor may suggest hydroxychloroquine Plaquenil. Each of these drugs has potentially serious side effects. Morphea - Diagnosis and treatment - Mayo Clinic. Plaquenil pros and cons - Sclero Forums MAIN - Sclero Forums. Scleroderma - Wikipedia. Scleroderma is a rare condition, and patients with scleroderma need specialized care from a rheumatologist familiar with their condition. The care of patients with scleroderma requires a team approach. Many patients with scleroderma will input from different medical specialties including gastroenterology, pulmonary, cardiology, and others. See how 938 people just like you are living with scleroderma. Learn from their data and experience. Dismiss this notification PatientsLikeMe would like to remind you that your browser is out of date and many features of the website may not function as expected. Plaquenil Perceived effectiveness. Localized scleroderma is a rare autoimmune disease with primary affection of the skin, and occasional involvement of the fat tissue, muscle, fascia, and bone. Depending on the clinical subtype, the spectrum of skin lesions ranges from singular plaque lesions to severe generalized or linear subtypes. which may lead to movement restrictions and permanent disability.