Chloroquine resistance development

Discussion in 'Northwest Pharmacy' started by CosmoStar, 02-Mar-2020.

  1. Andy.B XenForo Moderator

    Chloroquine resistance development


    According to legend it was first brought to Europe by a Countess who had been treated with it in Peru in the 1600s. In 1820, two French chemists isolated quinine from the cinchona bark and quinine became a treatment of reference for intermittent fever throughout the world. Quinine remains an important and effective treatment for malaria today, despite sporadic observations of quinine resistance.

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    Chloroquine resistance 12. The development and spread of drug-resistant strains of malaria parasites has been identified as a key factor in this resur- Recently, an altered chloroquine-transporter protein CG2 of the parasite has been related to chloroquine resistance, but other mechanisms of resistance also appear to be involved. Research on the mechanism of chloroquine and how the parasite has acquired chloroquine resistance is still ongoing, as other mechanisms of resistance are likely. Plasmodium falciparum malaria in Haiti is considered chloroquine susceptible, although resistance transporter alleles associated with chloroquine resistance were recently detected. Among 49 patients with falciparum malaria, we found neither parasites carrying haplotypes associated with chloroquine resistance nor instances of chloroquine treatment failure.

    These compounds belonged to a new class of antimalarials, the four-amino quinolines. Research by German scientists to discover a substitute for quinine led to the synthesis in 1934 of Resochin (chloroquine) and Sontochin (3-methyl-chloroquine).

    Chloroquine resistance development

    Antimalarial drug resistance, Chloroquine - Wikipedia

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  4. Chloroquine is commonly used to study the role of endosomal acidification in cellular processes 2, 3, such as the signaling of intracellular TLRs. Moreover, Chloroquine inhibits autophagy as it raises the lysosomal pH, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation.

    • Chloroquine & Hydroxychloroquine supporting chemo..
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    • DRUG RESISTANT MALARIA CURRENT STATUS.

    Each tablet contains 500 mg of Chloroquine phosphate USP, equivalent to 300 mg Chloroquine base. Inactive Ingredients colloidal silicon dioxide, dibasic calcium phosphate, hydroxypropylmethylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate80, pregelatinized starch. Development of resistance to chloroquine by Plasmodium vivax in Myanmar Marlar-Than. 1. Clinical Malaria Research Unit, Defence Services General Hospital, Mingaladon, MyanmarBurma. Search for other works by this author on Oxford Academic. PubMed. Google Scholar. Marlar-Than. Factors that promote the development of drug resistance are more intense with P. falciparum compared to P. vivax and this explains the higher incidence of resistance in P. falciparum. Mechanisms of resistance. The biochemical mechanism of resistance has been well understood in cases of chloroquine, the antifolates, and atovaquone.

     
  5. nobap Moderator

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  6. AlexVS User

    500 mg chloroquine phosphate (300 mg base) orally on the same day each week Comments: -If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate (600 mg base) may be taken orally in 2 divided doses, 6 hours apart. Chloroquine Phosphate Bulk Uses, Side Effects. Chloroquine Oral Route Description and Brand Names. Chloroquine Dosage Guide with Precautions -
     
  7. Subarticle Well-Known Member

    HYDROXYCHLOROQUINE SULFATE Nursing Implications. Assessment & Drug Effects. Monitor for therapeutic effectiveness; may not appear for several weeks, and maximal benefit may not occur for 6 mo. Do baseline and periodic ophthalmoscopic examinations and blood cell counts on all patients on long-term therapy.

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