Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine narcotic Chloroquine tablets asda To reduce the incidence of chloroquine and hydroxychloroquine toxicity, health care providers HCP's that prescribe these medications and those that screen for ocular toxicity have developed clear dosing and screening protocols that have reduced the risk of end-stage disease; bull's eye maculopathy and central vision loss Level I. The side effect that is of greatest concern is retinal toxicity. Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy. It’s believed but not proven that if early macular changes are detected and the medication is stopped, any toxicity that has occurred can be reversed.1 If the maculopathy continues to progress, concentric zones of hyperpigmentation and depigmentation seen below can form, causing irreversible toxicity. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil toxicity macula Will you have Macular hole with Plaquenil - eHealthMe, The Risk of Retinal Toxicity with Plaquenil - Sjogren's Does plaquenil cause itchy skinHydroxychloroquine 200 mg tab tablet price 180 quantityHydroxychloroquine testingHydroxychloroquine immunocompromiseChloroquine natural resources The actual incidence of retinal toxicity from hydroxychloroquine is difficult to pin down because there is usually a long time between being started on the drug and the start of any identifiable retinal toxicity. The overall rate of probable retinal toxicity is in the range of 1 of every 200 people treated. What can Hydroxychloroquine Plaquenil do to my eyes?. Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy. Chloroquine and Hydroxychloroquine Toxicity Workup Approach.. The risk of a toxicity sharply increases after 5 years, with majority of cases of retinotoxicity occurring in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine Plaquenil. This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day 200 bid. My DIL says that some docs are not well versed in Plaquenil toxicity and they can panic and take people off the Plaquenil when there is no toxicity. There is a fine line between toxicity and some other eye issues the ways she explains it. I guess with your eye problem and taking the Plaquenil it might be prudent to get all the info that is out. Bull's-eye maculopathy due to hydroxychloroquine toxicity. Contributor Jesse Vislisel, MD Photographer Randy Verdick, FOPS September 9, 2013. This patient took hydroxychloroquine for rheumatoid arthritis and her vision dropped to 20/300 as a result of the retinal toxicity.