There’s no cure for arthritis, which is unfortunate, but feeling better is definitely possible. The progression of RA may be diminished in severity and duration by the combination of medicines and therapy that work best as determined by you and your physician. Plaquenil renal toxicity Plaquenil and oral thrush Chloroquine brain tumor Chloroquine chemo Methotrexate rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction. Compare Methotrexate vs Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. For Rheumatoid Arthritis I've been on Plaquenil for over 3 months now. It works wonderfully! Rheumatoid Arthritis Support Group. Rheumatoid arthritis is a chronic, inflammatory, multisystem, autoimmune disorder. It is a disabling and painful condition which can lead to substantial loss of mobility due to pain and joint destruction. Hydroxychloroquine is an antimalarial drug which is relatively safe and well-tolerated agent for the treatment of rheumatoid arthritis. Chloroquine is another antimalarial agent that is also sometimes used. Being able to stop joint damage can lessen pain and mean a better quality of life. You can also put off joint damage, and in some cases, you can do more than just slow it down. Methotrexate and hydroxychloroquine for rheumatoid arthritis Combination therapy with methotrexate and hydroxychloroquine., Methotrexate or Plaquenil? DailyStrength Can chloroquine abort pregnancyPlaquenil retinopathy oct images Benefits Hydroxychloroquine is a relatively safe medicine that is used to treat mild rheumatoid arthritis. It is also used for complications of lupus. Risks Hydroxychloroquine has few side effects, but nausea and diarrhea may occur when you first start taking the drug. In very rare cases, vision loss has happened. DMARDs Arthritis Foundation. Rheumatoid Arthritis Treatment Options Johns Hopkins.. Common Questions About Taking Methotrexate for Rheumatoid.. Given at a low dose, methotrexate is effective in controlling the swelling, pain, and stiffness that result from inflammation. In a significant percentage of patients, it also seems to slow the progression of rheumatoid arthritis and prevent damage to joints and related structures. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis or juvenile idiopathic arthritis. Originally, hydroxychloroquine was used to prevent and treat malaria and was considered very effective. Now it is generally used for rheumatoid arthritis, but it has also been shown to work well for juvenile arthritis, some lupus symptoms, and other types of autoimmune conditions.