There’s no cure for arthritis, which is unfortunate, but feeling better is definitely possible. The progression of RA may be diminished in severity and duration by the combination of medicines and therapy that work best as determined by you and your physician. Took plaquenil during pregnancy Hydroxychloroquine toxicity eye wiki What symptoms of lupus does plaquenil treat Cpt code plaquenil therapy Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and. Prescribed for Lyme Disease - Arthritis, Dermatomyositis, Malaria Prevention, Malaria, Rheumatoid Arthritis. Methotrexate–hydroxychloroquine combination therapy may cause lower disease activity in early RA than methotrexate monotherapy. Methotrexate monotherapy as first early RA treatment seems to lead to more treatment intensification. The RA is better but I am putting that down to the steroid injection rather than the plaquenil as I have been told the Plaquenil can take a few weeks to work. Its interesting to read everyone elses views on the different drug treatments Being able to stop joint damage can lessen pain and mean a better quality of life. You can also put off joint damage, and in some cases, you can do more than just slow it down. Which is better for ra plaquenil or methotrexate Rheumatoid Arthritis Drugs Demystifying DMARDs, Effects of methotrexate and hydroxychloroquine combination. Lichen planus and plaquenilGetting off hydroxychloroquineHow does plaquenil work Methotrexate for Your RA. Methotrexate is one of the most effective medications to treat rheumatoid arthritis RA. It's the first drug most doctors prescribe after you’re diagnosed. It will. How Does Methotrexate Treat Rheumatoid Arthritis? - WebMD. Methotrexate or Plaquenil? DailyStrength. Compare Plaquenil vs Methotrexate -. MTX+Plaq can be a very effective method of treatment for RA, I guess because the MTX inhibits T-Cell activation and Plaq prevents messengers from telling T-cells to produce TNF - a combination which one imagines is going to be pretty effective - just make sure you have regular blood work with 25mg/w of MTX, it's on the high side, so I hope the side effects aren't too bad for you. From what I read so far, seems like methotrexate is a bigger drug with more side effects so plaquenil would be the better choice. Any information would be helpful. Sorry to hear that you are having a lot of pain with your RA. I have lupus which mainly affects my joints and skin. I have been taking hydroxychloroquine which is the generic of plaquenil for the past three years. My rheumy recently added Imuran instead of methotrexate. Plaquenil hydroxychloroquine takes up to 3 months to begin working.