Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. How to switch from plaquenil to methotrexate Cost for plaquenil Natural substitute for plaquenil for discoid lupus Our patient demonstrates the importance of using the new recommended screening tools for the detection of early hydroxychloroquine toxicity. 10-2 HVF, SD-OCT, autofluorescence, or mfERG might have detected the hydroxychloroquine retinal toxicity on the day of her presenting symptoms and possibly earlier, potentially limiting the amount of visual loss. Image USC Roski Eye Institute. more than 5 years in whom we could document toxicity with OCT as well as visual fields and autofluorescence in different patients. the earliest possible. When this thinning is translated into an OCT map, a bulls-eye pattern of thinning is manifested, as shown in the image entitled "Time Domain OCT Map in Hydroxychloroquine Toxicity". The patient shown here is the same one shown in the image "Asymmetric Hydroxychloroquine Plaquenil Retinal Toxicity". Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Oct image plaquenil toxicity Hydroxychloroquine-Induced Retinal Toxicity - American., Despite Plaquenil dosing recommendations, retinal toxicity remains Purpose of hydroxychloroquineIs plaquenil administered subcutaneouslyPlaquenil used for hair loss Uploaded on Dec 6, 2016. Last modified by Caroline Bozell on Dec 7, 2016.; Rating Appears in Miscellaneous Condition/keywords plaquenil toxicity Description 70-year-old woman with history of plaquenil use for rheumatoid arthritis. Plaquenil Toxicity OCT - Retina Image Bank. Time Domain OCT in Hydroxychloroquine Plaquenil Toxicity.. Early Plaquenil Toxicity Detected without Bull’s Eye.. Spectral domain optical coherence tomography as an effective screening test for hydroxychloroquine retinopathy the “flying saucer” sign. drug toxicity, hydroxychloroquine, photoreceptors. Normal Spectralis spectral domain optical coherence tomography SD OCT image with intact photoreceptor inner segment/outer segment junction. Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy Retinal toxicity from chloroquine CQ and its analogue, hydroxychloroquine HCQ, has been recognized for many years. Chloroquine toxicity remains a problem in many parts of the world, but is seen less frequently in the United States where the drug largely has been replaced by HCQ. Plaquenil Toxicity both Eyes - Partial Bull's Eye - Discontinued 6 Years ago SD-OCT Spectral domain optical coherence tomography 2320 views 82-year-old woman was on Plaquenil from 1976 from 2005, 200 mg a day. It was discontinued because of abnormal visual fields 6 years ago.