Chloroquine blood plasma ratio

Discussion in 'International Pharmacy' started by stfish, 14-Mar-2020.

  1. zonan Well-Known Member

    Chloroquine blood plasma ratio


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    The distribution of chloroquine was studied in the tissues and blood of rat. 2. 2. The time to peak concentration and the maximum concentration varied in various tissues and were higher than for plasma and red blood cells. The drug is extensively distributed, with a volume of distribution of 200 to 800 L/kg when calculated from plasma concentrations and 200 L/kg when estimated from whole blood data concentrations being 5 to 10 times higher. Chloroquine is 60% bound to plasma proteins and equally cleared by the kidney and liver. Blood/Plasma Partitioning Compound List. This is a list of compounds that are in the BPP dataset. BPP Assay Compounds partial list Acebutolol. Acetophenetidine

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine blood plasma ratio

    Chloroquine and desethylchloroquine concentrations in blood cells and., Clinical Pharmacokinetics and Metabolism of Chloroquine.

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  6. For example, the clearance of CQ from whole blood and plasma is approximately 0.1 to 0.25 liter/h/kg of body weight and 0.5 to 0.9 liter/h/kg, respectively, in healthy volunteers, and the t 1/2 of CQ is 150 to 290 h 17–19, 32, 35, 47, 59.

    • Pharmacokinetics, Pharmacodynamics, and Allometric Scaling..
    • Blood Plasma Partitioning Compound List.
    • Pharmacokinetics of chloroquine Saliva and plasma levels..

    Therefore, determining the blood-to-plasma ratio is important for deciding whether plasma or whole blood would provide more physiologically relevant pharmacokinetic parameters. For these studies, chloroquine is used as a positive control. Caco-2 Permeability Studies The blood to plasma ratio determines the concentration of the drug in whole blood compared to plasma and provides an indication of drug binding to erythrocytes. At blood to plasma ratios of greater than 1 usually as a consequence of the drug distributing into the erythrocyte. It turns out that Vss, the total body clearance, Cl, equilibrium blood-plasma concentration ratio, r; and the physiological parameters of the body such as cardiac output, and blood and tissue.

     
  7. Wardal XenForo Moderator

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  8. Sydney New Member

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  9. sergeySr Guest

    Plaquenil Hydroxychloroquine Sulfate - Sanofi PrPLAQUENIL® Hydroxychloroquine Sulfate Tablets USP 200 mg ACTIONS AND CLINICAL PHARMACOLOGY PLAQUENIL hydroxychloroquine sulfate tablets belongs to the 4-aminoquinoline class. PLAQUENIL has been beneficial for patients with rheumatoid arthritis and lupus erythematosus, especially chronic discoid lupus.

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  10. Mobi Well-Known Member

    PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION Hydroxychloroquine levels were still detectable after 3 months with approximately 10% of the dose excreted as the parent drug. Results following a single dose of a 200 mg tablet versus i.v. infusion 155 mg, demonstrated a half-life of about 40 days and a large volume of distribution.

    Coupon For Hydroxychloroquine 200mg - 02/2020