Patients with morphea typically develop red patches on the skin, usually on the abdomen, chest, and back. Occasionally, patches may form on the face or the arms and legs. Can plaquenil and metoprolol tartrate be taken together Can plaquenil help with small fiber neuropathy Morphea, also known as localized scleroderma, is a disorder characterized by excessive collagen deposition leading to thickening of the dermis, subcutaneous tissues, or both. Morphea is classified into circumscribed, generalized, linear, and pansclerotic subtypes according to the clinical presentation and depth of tissue involvement. Anti-malarial drugs, such as Plaquenil hydroxychloroquine, is often used to manage lupus and can also be effective in scleroderma. Plaquenil is thought to interfere with communication between immune cells, which can suppress the damaging effect of an overly active immune response without raising a patient’s risk of susceptibility to infections. Patients with morphea exposed to UVA1 with a dose of 30 J/cm 2 and a cumulative dose of 900 J/cm 2 were found to have an increase in CD34 + dendritic cells 20. Human beta defensins HBD, interleukin IL-6 and IL-8 are downregulated in patients with localized scleroderma treated with UVA1 phototherapy 6. Some patients may have only one patch of thickened skin, and others may have several patches. These discolored patches tend to become firm, dry, and smooth over time, and they are often oval in shape. Hydroxychloroquine and phototherapy combination morphea Morphea associated with primary biliary cirrhosis and., Lupus and Scleroderma - Scleroderma News Taking baseline eye examination before starting plaquenilPlaquenil and tongue swellCan hydroxychloroquine interfere with the immune systemChloroquine poisoning treatment Oct 01, 2006 Localized scleroderma morphea affects only the skin, whereas systemic sclerosis SSc; scleroderma can additionally involve the lungs, gastrointestinal tract, kidneys and heart. Fibrosis of the skin is sometimes marked and leads to considerable morbidity with loss of flexibility, joint contractures and disfigurement. Phototherapy a promising treatment option for skin sclerosis.. Phototherapy in Scleroderma. Morphoea DermNet NZ. Today, phototherapy is a valuable option in the treatment of many non-psoriatic conditions including AD, sclerosing skin conditions such as morphea, vitiligo, and mycosis fungoides. Due to its relative safety, phototherapy may be used in most populations, including children and pregnant women. Excimer laser for the treatment of morphea. Morphea plaque of our patient after 16 treatments • We present a case of a 28-year-old woman with active sclerotic plaques distributed along her neck, left flank. She had previously failed therapy with topical steroids and methotrexate, and was started on hydroxychloroquine 400 mg daily and Morphea skin - morphea scleroderma causes. Morphea types inear morphea & morphea profunda. Morphea skin disease treatment. Conditions. such as oral methotrexate Rheumatrex, Trexall. This may be used in combination with corticosteroid pills for the first few months. Add hydroxychloroquine; Add phototherapy UVA1 or PUVA if available.