It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Chloroquine emc Number of hydroxychloroquine In defense of your ophthalmologist, the eye problems with Plaqueni, although rare are dose related. Comparison of Plaquenil and methotrexate is difficult. Both drugs are very well tolerated and have different side effects, but if you have other medical problems, one drug might be better for you and you should discuss this with your rheumatologist. Renal failure and certain drug interactions such as interactions with tamoxifen, glycosides, methotrexate and ciclosporin can influence the pharmacokinetics of hydroxychloroquine and chloroquine. Summary Drug interactions are reported among people who take Methotrexate and Plaquenil together. This study is created by eHealthMe based on reports of 23,242 people who take Methotrexate and Plaquenil from Food and Drug Administration FDA, and is updated regularly. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Interactions between plaquenil and methotrexate Compare Plaquenil vs Methotrexate -, Mechanisms of action of hydroxychloroquine and chloroquine. How long does it take for hydroxychloroquine to work Plaquenil is prescribed for Lupus, RA, Sjogren's Syndrome and Joint Pain and is mostly mentioned together with these indications. Interaction between Methotrexate and Plaquenil There is no known interaction between Methotrexate and Plaquenil in our records. However, an interaction may still exist. Compare Methotrexate vs Plaquenil for Lupus.. Methotrexate and Plaquenil drug interactions - eHealthMe. Plaquenil vs Methotrexate rheumatoid. The use of nitrous oxide anesthesia with methotrexate is contraindicated see CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS - Renal and DRUG INTERACTIONS - Drug-Drug Interactions Overview Methotrexate competes with reduced folates for active transport across cell membranes by means of a single carrier-mediated active transport process. I had a biopsy and my doctor said he believes it is morphea. I am waiting on my blood test to come back and he said as soon as it does he will put me on both methotrexate and doctor is a very good derm. Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in.