Part of that is due to less exercise, part due to having no appetite thus feeling like anything I can get down is ok. Well, now I've been exercising at almost my pre-Lupus rate (ran a marathon a year before), eating a more moderate diet (clean protein, vegs & fruits), and am no longer taking that weight & bloat causing Prednisone (off Pred almost 2 yrs now). My question: Do you feel like you've gained weight on Plaquenil (ie without Prednisone)? Hydroxychloroquine otc Baseline reading for plaquenil therapy 2018 Weight increased is found among people who take Hydroxychloroquine sulfate, especially for people who are female, 60+ old, have been taking the drug for 10+ years, also take medication Enbrel, and have High blood pressure. Check with your doctor immediately if any of the following side effects occur Incidence not known. Blistering, peeling, loosening of the skin blurred vision or other vision changes chest discomfort, pain, or tightness cough or hoarseness dark urine decreased urination defective color vision diarrhea difficulty breathing I've been taking hydroxychloroquine since last Autumn - dose increased to 400 mg per day in April. I think it helps me, but it can take 6 months to kick in. Still have to be really careful not to get over-tired. Can give you wind and stomach bloating. My Lupus has been really quiet for about 2 yrs, and I'm afraid to change anything. The Plaquenil drug side effects list weight loss, but some people have reported weight gain instead. My rheumy wants me to come down and then off my Plaquenil, but I've been resisting simply because I'm afraid to. Side effects of hydroxychloroquine weight gain Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis, Hydroxychloroquine Oral Route Side Effects - Mayo Clinic Checking vision plaquenilPlaquenil and drug induced lupusPlaquenil and parasites Hi everyone. I know this seems shallow and there are more important things in life like getting healthy but I have a question for those who are taking or have taken Medrol and or Plaquenil. Has anyone experienced weight gain? I have been reading up on side effects and weight gain and swollen face. Medrol, Plaquenil and weight gain - Sclero Forums. How good is Hydroxychloroquine, and any side effe. - HealthUnlocked. Plaquenil - Uses, Side Effects, Interactions -. View detailed reports from patients taking hydroxychloroquine sulfate who experienced abnormal weight gain. Reports are from official medical reports as well as online extractions from user reviews and forum discussions. The results of the present study demonstrate abnormal weight gain as a side effect of long-term treatment with doxycycline and hydroxychloroquine. Moreover, doxycycline and hydroxychloroquine treatment exhibits a reproducible effect on the community structure of the gastrointestinal microbiota in humans. Hi Lynwood, The plaquenil has caused a weight gain of about 20-25 pounds for me. Since I was diagnosed with MCTD a year ago, Plaquenil has been the only medication besides eye supplements, thyroid meds - been stable for years, and most recently Evoxac that I have been given.