I have been on plaquenil for over a year and a half and methotrexate since September. I get my eyes checked every six months and I am now at once a month on blood work for my liver enzymes (used to be every 2 weeks). I have lupus which mainly affects my joints and skin. One affects your eyes more and one affects your liver more. I would appreciate any comments or advice from everyone. Wannabe Hi, I am on both methotrexate and plaquenil. Wannabe To Be Free To Roam Sorry to hear that you are having a lot of pain with your RA. Chloroquine grp Hydroxychloroquine brands Undifferentiated connective tissue disease hydroxychloroquine How bad is plaquenil on organs May 28, 2016 I have been diagnosed with Limited Scleroderma. My choices are Methotrexate, Plaquenil or Sulfasalzine Azulfidine. I researched them and determined Plaquenil would be my last choice, although it was his first, because I already have lattice degeneration of the retina in both eyes and one of the potential side effects is retinal problems. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Methotrexate is an arthritis medication and a cancer medication. Plaquenil is an arthritis medication and an anti infectious agent. There may be a negative interaction between Methotrexate and alcohol. There may be a negative interaction between Plaquenil and alcohol. I wish you well with this decision and the results. Your chances of problems with the methotrexate are a bit larger. deductible (I am at about $2,500 - $3,000 right now). My rheumy recently added Imuran (instead of methotrexate). So, what do yall know about the side effects of both and the benefits of both? Plaquenil vs methotrexate Plaquenil vs. Rheumatrex, Trexall Prescription Treatment., Compare Plaquenil vs Methotrexate - Can i take omeprazole with hydroxychloroquinePlaquenil retinopathy visual fieldSide effects of chloroquine phosphate tablets Patients whose arthritis is poorly controlled with non-steroidal anti-inflammatory drugs NSAIDs, low doses of steroids and Plaquenil hydroxychloroquine are often managed with methotrexate. Methotrexate is usually taken just once a week in tablet form. Methotrexate and its benefit for Sjögren’s patients. Compare Methotrexate vs Plaquenil for Lupus.. Methotrexate vs Plaquenil Comparison -. Check the latest outcomes from 50,877 Plaquenil users, or browse all drugs. What is Methotrexate? Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. Check the latest outcomes from 339,740 Methotrexate users, or browse all drugs. Here are 10 things to keep in mind when using Plaquenil Take it on a regular schedule, meaning at the same time each day. Take Plaquenil EXACTLY as prescribed by your physician. Do not stop taking the medication without first speaking to your doctor. Taking Hydroxychloroquine with food and/or milk can help prevent stomach upset. Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients.