Hydroxychloroquine is a one of a number of drugs which have been used for many years in the treatment of malaria. Fortunately, it was discovered these drugs often are helpful in the treatment of various rheumatic diseases, particularly systemic lupus erythematosus (SLE or "Lupus") and rheumatoid arthritis. Drug interaction chloroquine and ibuprofen Plaquenil and catching colds My dr told me that she thinks that I probably have Fibromyalgia and an Undifferentiated Connective Tissue Disorder suspected Lupus. She gave me Plaquenil for the pain that I have been having, and a steroid pack in the interm. For the first year I started with only 200 mg plaquenil and large doses of sodium salicylate this drug is no longer used and is like giant horse pill aspirin After that, I only took 200 Plaquenil for 14 years. I am now on several medications for lupus and other things. Plaquenil takes several months to become effective. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. When effective, it can decrease damage to the tissues of the joints, skin and other organs in the body. Although chloroquine is sometimes used, the preferred antimalarial drug is hydroxychloroquine due to its greater safety. It is not possible at the present time to explain precisely why hydroxychloroquine is effective in various rheumatic diseases. Plaquenil for lupus reviews fatigue Experiences taking Plaquenil for Fatigue and Muscle Pain., Best medication to treat Lupus fatigue?" Lupus Community. Medication for rheumatoid arthritis plaquenilChloroquine pretreatment degradation Hi! I think Plaquenil is the cause of my extreme fatigue too. I am not anemic at this time and I get exhausted just trying to get through the day. I have also been on Plaquenil about three months. All of my arthritis swelling and pain are gone, but the fatigue will not let up! Hope things change for you. Is extreme fatigue a side effect of Plaquenil?. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. Hydroxychloroquine User Reviews for Systemic Lupus.. Is extreme fatigue a side effect of Plaquenil. results with Plaquenil with very little side affects. I'm reading reviews online and I'm starting to get. Fatigue. Systemic weakness is a state that usually follows lupus flare-ups. In the case of possible drug interaction, CBD oil can be used solitary for total system recovery. Homeostasis maintenance is the link between CBD oil and lupus fatigue treatment. This is based on the anti-anxiety effects of CBD. These medications may also prevent lupus from spreading to certain organs, such as the kidney and central nervous system your brain and spinal cord and may help to reduce flares by as much as 50%. Plaquenil and other anti-malarials are the key to controlling lupus long term, and some lupus patients may be on Plaquenil for the rest of their lives.