But Chloroquine has significantly higher rate of retinal toxicity, so it isn't used much anymore. Also, Plaquenil appears to effectively reduce flares in patients with lupus not necessarily by suppressing immunity. Read more Anxiety over potential eye problems with Hydroxychloroquine is completely unwarranted if the dose is kept below 6mg/kg (2.2lbs) of body weight. Read more See 1 more doctor answer It can cause eye problems so you need to see an ophthalmologist and peridoic screenings. Read more Results are very good, particulary when used alone and better with methotrexate. Does plaquenil help infertility Ccca plaquenil The use of alternative medical therapies by lupus patients in the United Kingdom, Canada and the United States. The total refers to all patients using at least one alternative therapy and the numbers in brackets are the percentage % of patients in that category. Hydroxychloroquine Plaquenil hydroxychloroquine Arava leflunomide methotrexate methotrexate Sulfasalazine sulfasalazine chloroquine chloroquine I was on plaquenil about 5 yrs go and it started messing with me eyes so they took me off. today i went to duke and my dr put me on it agian. she put me on 400mg a day. is that high? i had my eye exam and everthing was fine to take this med again. so im going to try again. i have tryed all the other meds and nothen works. my dr's say im 1 out. Chloroquine can be substituted for Plaquenil but only in limited circumstances. Please provide more detailed information if you want a more specific answer. Read more See 1 more doctor answer Depends on what you are being treated for.... Read more While plaquenyl is a slow acting but effective drug, Prednisone is used in much higher doses in active sle. Arthritis (non-deforming) or arthralgias associated with the disease will have substantial pain relief with a dose this low. It's infusion intervals are longer, because the turnover of recptors is slower than the production of tnf-a itself. So other meds like Imuran and Cell Cept (mycophenolate mofetil) also reduce flares, but also increases infection. Read more It depends why you are taking Plaquenil in the first place. Apart from some stomach quiziies, I have never stopped this drug, as long as it demonstrated it is working. Other than that we see a few people who have increased skin pigmentation called "plaquenil ochronosis". The dirrence with Remicade (infliximab) is that it blocks the tnf-a receptor, rather than binding tnf-a itself, but it accomplishes the same thing. Other alternatives to hydroxychloroquine for lupus Hydroxychloroquine Common Lupus Drug in Testing for COVID., Plaquenil hydroxychloroquine Alternatives & Similar. Mechanism of action of hydroxychloroquine in rheumatoid arthritisEffects of plaquenil in pregnancyPlaquenil es tóxicoPlaquenil cause cushings Prescribed for Lyme Disease - Arthritis, Dermatomyositis, Malaria, Malaria Prevention, Rheumatoid Arthritis, Systemic Lupus Erythematosus. May also be prescribed off label for Sjogren's Syndrome. Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. Plaquenil Compared to Alternatives -. Alternative" to plaquenil. ProHealth Fibromyalgia, ME.. Discontinued Plaquenil.other options?. Potential side effects of anti-malarial drugs include Skin rashes and pigment change. Atabrine, specifically, can cause yellow pigmentation of skin. Sometimes Plaquenil can also deposit in the tissues. Dry skin. Loss of appetite. Abdominal bloating. Upset stomach. Stomach cramps. Retinal damage. Is there a drug that I can. I take methotrexate also but the plaquenil messed with my vision and I had to quit taking it. I been treated for ra for 19 yrs. And I'm beginning to see more changes in my feet and hands. May I suggest you move your research to Google Advanced. You go to Google search engine and then type in Google Advanced. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more.