Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Leflunomide hydroxychloroquine Lyrica and hydroxychloroquine Plaquenil sulfate uses Hydroxychloroquine plaquenil side effects Both Plaquenil and Rheumatrex and Trexall may interact with nonsteroidal anti-inflammatory drugs, antibiotics, or seizure medications. Plaquenil may also interact with acetaminophen, cancer medications, tuberculosis medications, birth control pills or hormone replacement therapy, arthritis medications, ACE inhibitors, antifungals, cholesterol medications, or HIV / AIDS medications. Are there any other meds that treat RA & lupus other than plaquenil? Asked by tinaberry Updated 24 October 2017 Topics plaquenil, rheumatoid arthritis, systemic lupus erythematosus Plaquenil Prices. HYDROXYCHLOROQUINE is used to treat rheumatoid arthritis and systemic lupus erythematosus. It is also used to treat malaria. The lowest GoodRx price for the most common version of generic Plaquenil is around $18.60, 90% off the average retail price of $196.17. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Medication similar to plaquenil Are there other drugs besides methotrexate that are used to., Are there any other meds that treat RA & lupus. - The making of chloroquinePlaquenil dosage sjogren's syndromeIs hydroxychloroquine a painkiller I "know" I need some meds, but cannot tolerate Plaquenil. Wondering if anyone has come across something "natural" that mimics it. Thanks & LIGHT*****carole - Hi, Carole. When I started Plaquenil, my GI system was in an uproar. But it usually was anyway. I didn't realize, until I saw Dr. Natural" alternative to Plaquenil. - HealthBoards. Plaquenil Prices, Coupons & Savings Tips - GoodRx. Discontinued Plaquenil.other options?. Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Severe Interactions These medications are not usually taken together. Consult your healthcare professional e.g. doctor or pharmacist for more in formation. These medications may interact and cause very harmful effects. Consult your healthcare professional e.g. doctor or pharmacist for more in formation. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.