Chloroquine rheumatoid arthritis mechanism of action

Discussion in 'Canadian Online Pharmacy' started by DoEvent, 24-Feb-2020.

  1. redrat User

    Chloroquine rheumatoid arthritis mechanism of action


    It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc.

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    It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis or juvenile idiopathic arthritis and other autoimmune diseases. It is not clear. Mechanism of Action. Restricted to use in adults since safe use of the drug in the treatment of juvenile rheumatoid arthritis has not. like chloroquine, and. Chloroquine phosphate is a 4-aminoquinoline compound for oral administration. Chloroquine is an antimalarial and amoebicidal drug. The drug possesses antimalarial actions and exerts a beneficial effect in lupus erythematosus chronic discoid or systemic and acute or chronic rheumatoid arthritis. The precise mechanism of action is not known.

    For prolonged treatment of lupus or arthritis, adverse effects include the acute symptoms, plus altered eye pigmentation, acne, anaemia, bleaching of hair, blisters in mouth and eyes, blood disorders, convulsions, vision difficulties, diminished reflexes, emotional changes, excessive coloring of the skin, hearing loss, hives, itching, liver problems or liver failure, loss of hair, muscle paralysis, weakness or atrophy, nightmares, psoriasis, reading difficulties, tinnitus, skin inflammation and scaling, skin rash, vertigo, weight loss, and occasionally urinary incontinence. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. For short-term treatment of acute malaria, adverse effects can include abdominal cramps, diarrhea, heart problems, reduced appetite, headache, nausea and vomiting.

    Chloroquine rheumatoid arthritis mechanism of action

    Hydroxychloroquine - Wikipedia, Hydroxychloroquine TUSOM Pharmwiki

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  4. Rheumatoid Arthritis RA Rheumatoid arthritis RA is an autoimmune disease that causes chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Because it can affect multiple other organs of the body, rheumatoid arthritis is referred to as a systemic illness and is sometimes called rheumatoid disease.

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    Blood levels of racemic chloroquine and its main metabolites desethylchloroquine and bisdesethylchloroquine were measured in 29 patients treated chronically for rheumatoid arthritis. In six patients, the concentrations were followed during a one day dosage interval. There was considerable intersubject variability in the steady state blood concentrations of chloroquine range 36.6 to 3895 ng. Chloroquine is a 9-aminoquinoline that has been known since 1934. Specifically synthesised to be used as an antimalarial agent, chloroquine was subsequently shown to have immunomodulatory properties that have encouraged its application in the treatment of autoimmune diseases such as rheumatoid arthritis. Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients.

     
  5. MineOptim Guest

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Plaquenil Side Effects Common, Severe, Long Term - Hydroxychloroquine Plaquenil Will you have Drowsiness with Plaquenil - eHealthMe
     
  6. unomaster Guest

    Figure S1 – Chloroquine does not affect differentiated cancer cells This effect of chloroquine was not observed in the primary cells A. Confocal images of cells transfected with LC3II-GFP and cultured in the presence or absence of chloroquine for 6-24h B. Quantification of GFP+ foci in the cells transfected with LC3II-GFP and cultured in the presence or absence of chloroquine for 6h.

    Canadian Pharmacy 24h Canadian-Pharmacy-24.
     
  7. white_wolf User

    Hydroxychloroquine MedlinePlus Drug Information If you are taking hydroxychloroquine for symptoms of rheumatoid arthritis, your symptoms should improve within 6 months. If your rheumatoid arthritis symptoms do not improve, or if they worsen, stop taking the drug and call your doctor. Once you and your doctor are sure the drug works for you.

    Hydroxychloroquine Oral Route Precautions - Mayo Clinic