The patient had been on Amiodarone therapy for several years. These deposits occur in various levels of the cornea. Two months prior to this routine follow up, the patient's primary care doctor made a change in the patient's cardiac medications which included the removal of amiodarone from his medication regimen. Corneal verticillata, also called vortex keratopathy, are one type of corneal deposits. Plaquenil and cancer Chloroquine physical properties Hydroxychloroquine liver toxicity Plaquenil mastocytosis In 1 case related to perhexiline maleate, papilledema appearing concurrently with the vortex keratopathy and considered drug related resulted in significant visual acuity loss that did not completely reverse after withdrawal of the drug. 24 Besides asymptomatic vortex keratopathy, retinal toxicity—including macular and peripheral retina. Apr 14, 2013 • Chloroquine Aralen, Sanofi Aventis and hydroxychloroquine Plaquenil, Sanofi Aventis are antimalarial agents used in the management of rheumatoid arthritis and lupus. Corneal manifestations include vortex keratopathy and decreased corneal sensation. Toxicity from hydroxychloroquine may be seen in two distinct areas of the eye the cornea and the macula. The cornea may become affected relatively commonly by an innocuous cornea verticillata or vortex keratopathy and is characterized by whorl-like corneal epithelial deposits. These changes bear no relationship to dosage and are usually reversible on cessation of hydroxychloroquine. The opacities branch out from a central whorl, usually across the inferior cornea. Verticillata are readily recognizable by their distinct appearance as fine, golden-brown or gray opacities that are almost always bilateral. Vortex keratopathy hydroxychloroquine In vivo confocal microscopy in hydroxychloroquine-induced., When ‘Collateral Damage’ Strikes the Cornea Hydroxychloroquine autophagy These deposits occur in various levels of the cornea. Corneal verticillata, also called vortex keratopathy, are one type of corneal deposits. Verticillata are readily recognizable by their distinct appearance as fine, golden-brown or gray opacities that are almost always bilateral. Corneal verticillata - Amiodarone. Hydroxychloroquine - Wikipedia. Newer technology advised for screening patients taking.. Taking Hydroxychloroquine develop toxicity2 It’s rare for side effects to occur with Plaquenil if the medication is dosed properly Side effects Blurred vision, bull’s eye maculopathy, scotoma, vortex keratopathy, headache, accommodative dysfunction, whitening of eyelashes, phototoxicity3 A number of prescription drugs are well known for their potential retinal toxicity, including Plaquenil hydroxychloroquine, Sanofi Aventis, tamoxifen and thioridazine.1 Vortex keratopathy has been linked to use of amiodarone and indomethacin.2 Anti-anxiety medications, such as Prozac fluoxetine, Eli Lilly and Zoloft sertraline, Pfizer. Cornea verticillata. Contributor Jesse Vislisel, MD. Cornea verticillata, also known as vortex keratopathy, describes a pattern of whorl- shaped opacities within the basal corneal epithelium. They are most commonly located in the inferior paracentral region, are non-elevated, and can range from white to brown in color.