It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Plaquenil and grapefruit Taking plaquenil while having yeast infections Chloroquine mechanism mitochondria Jan 09, 2015 RE Plaquenil Hydroxychloroquine during pregnancy Posted on Jan 9, 2015 at pm. not the first line for NK cells but seems to have benefits there and for those with autoantibody mediated syndromes. Mechanism of action still unclear. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage is also based on weight. Anti-malarial drugs hydroxychloroquine, chloroquine are considered pregnancy category C drugs. While there is evidence of risk for damage to the eye and ear, if the benefits of these drugs in controlling RA symptoms are judged to outweigh the risks, they may continue to be used during pregnancy. 1,2 The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. Pregnancy hydroxychloroquine Hydroxychloroquine Plaquenil, Hydroxychloroquine Oral Uses, Side Effects, Interactions. Taking plaquenil while having infectionsSide effects of hydroxychloroquine sulfate 200 mg tablets It is not necessary to withdraw an antimalarial drug during pregnancy if the rheumatic disease is well controlled; however, the manufacturer of hydroxychloroquine advises avoiding use. Breast feeding Avoid—risk of toxicity in infant. HYDROXYCHLOROQUINE SULFATE Drug BNF content published by NICE. Drug Safety in Pregnant & Nursing Women. Hydroxychloroquine prevents congenital heart block recurrence.. The role of hydroxychloroquine HCQ for achieving this control is now recognized. Several studies demonstrate that patients with SLE who continue HCQ during pregnancy have decreased flares and improved pregnancy outcomes, including longer fetal gestation and infants with higher birth weight3,4. Jul 03, 2012 A recent case control study suggested a benefit of hydroxychloroquine HCQ in lowering the risk of cardiac manifestations of neonatal lupus cardiac-NL in pregnancies of anti-SSA/Ro positive patients with Systemic Lupus Erythematosus SLE. It does not appear to be safe during pregnancy. Hydroxychloroquine is in the antimalarial and 4-aminoquinoline families of medication. Hydroxychloroquine was approved for medical use in the United States in 1955.