Why chloroquine is given in loading dose

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  1. Bynthyj XenForo Moderator

    Why chloroquine is given in loading dose


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    What I’m wondering is if there is any relationship with increasing the loading dose and the time taken to reach the steady state. For example, if a greater loading dose was given for a particular drug, would this decrease the time taken to reach the steady state compared to smaller loading dose? Thank you very much in advance. Kind Regards, Sarah Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract, and only a small proportion of the administered dose is found in the stools. Approximately 55% of the drug inthe plasma is bound to nondiffusible plasma constituents. Excretion of Chloroquine is quite slow,but is increased by acidification of the urine. To avoid nausea and vomiting chloroquine should be administered after meals. If part or all of a dose is vomited, the same amount must immediately be readministered. Adults, including pregnant women, and children Total dose 25 mg/kg given over 3 days. Day 1 10 mg/kg, followed by 5 mg/kg 6-8 hours later. Days 2 and 3 5 mg/kg in a single dose.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Why chloroquine is given in loading dose

    TREATMENT OF SEVERE MALARIA - Guidelines for the Treatment of., Chloroquine - FDA prescribing information, side effects and uses

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  7. Why administer a vancomycin loading dose? Due to the pharmacokinetics of vancomycin, a loading dose – a large dose given once at the onset of therapy to rapidly achieve a therapeutic drug concentration in the body – is required to ensure that vancomycin levels are not subtherapeutic at the beginning of treatment. 6,7

    • Vancomycin loading dose - the pharmacokinetics to consider..
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    • Chloroquine - Wikipedia.

    In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose. A loading dose is most useful for drugs that are eliminated from the body relatively slowly, i.e. have a long systemic half-life. Chloroquine shouldn’t be utilized in these circumstances except the profit to the affected person outweighs the potential risks. Why chloroquine is given as a loading dose. The key mutation seems to be K76T since no chloroquine resistant isolate carries the wild sort lysine at position 76. Malaria treatment oral To treat malaria in adults, one dose of oral chloroquine is usually given right away. Then, half the dose is taken six to eight hours later. This is typically followed by half the dose once a day for the next two days. Amebiasis treatment oral To treat amebiasis in adults.

     
  8. Wolf1994 New Member

    Pepcid (famotidine) is a histamine-2 blocker that works by decreasing the amount of acid the stomach produces. Will you have Gastroesophageal reflux disease with Plaquenil - eHealthMe Plaquenil Oral Uses, Side Effects, Interactions, Pictures. Plaquenil and antacids? - Sjogren's World
     
  9. Cuca New Member

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Can you take an NSAID while taking Xanax - Answers Hydroxychloroquine Oral Route Side Effects - Mayo Clinic Mixing CBD and Xanax - Everything You Need To Know - 2020
     
  10. Ru5i4 XenForo Moderator

    Hydroxychloroquine Plaquenil Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.

    Plaquenil and Ibuprofen drug interactions - eHealthMe