I have been on plaquenil for about 10 weeks now without much success. I have had the sickness to my stomach and not felt like me including exhausted but it's not as bad as I feared. My hair is coming out slightly Not in clumps are anything, just a little here or there. My doctor said if I don't feel better in a few more weeks, we could switch my medicine. Really though in order not to have worse things happen it is what we have to do. I switched back to cymbalta three days ago and have experienced huge relief. Hydroxychloroquine usos Would hydroxychloroquine cause a positive opioid drug test Can plaquenil cause diarrhea Hydroxychloroquine 200 mg acetaminophen 400 mg It has numerous benefits on lupus and in general tends to lower cholesterol for instance. It is interesting that you were first prescribed mepacrine/quinacrine instead of Plaquenil. Mepacrine will do more to battle the fatigue as it is stimulating, Plaquenil is not as helpful in that respect as it is not stimulating. What next if plaquenil doesn't work? Support Forums. I wish the plaquenil was working but it's not. I feel so bad every day. Prednisone ran my blood sugar up but I felt great on it, not that you want to take it for too long. mama6. Regular Member. Joined Jul 2010. I guess it helps me. I don't even know anymore. I have been on it for. Maybe hormone changes, maybe mood disorder, maybe huge stressful life that needs to be cut back. not saying you cant blame every single uncomfortable thing in life on lupus, but lupus is not the entire you. menopause is a wild ride thru hell with or without lupus, cancer, grief, indigestion, bee sting - check for other issues as well. Vitamin B-12 might help with the hair, ask your doctor about that, well wishes to you and I hope the mtx can help you....((((((((((((((((((((((((((((((((((((((((((((((Jeanneac)))))))))))))))))))))))))))))))))))))))))healing hugz and well wishes and keep us posted on how your doing... Had headaches with the plaquenil so went to the sulfar and predisone. (like i did friday) Take care of yourself and big(((HUGS))) on your journey. He said it would be one that they would have to more closely monitor me on with some blood tests. I was thinking it was methotrexate but I do not want my hair to fall out. It might be coincidence but since on the plaquenil, I have noticed a growth spurt of hair especially at the hairline. Plaquenil made me sick, so I can't take it either, but there are other medicine out there,the doctor's will get you on something that'll help, keep hope..wishes to you and try the methotrexate,to see if it can help... I know it is scary but anything to stop the pain and misfunction of not being able to use my hands or move my knees or not have my ankles cave out and fall. I suspected that I had fibromyalgia on top of the inflammation. I am so relieved but hope I don't start having bad side effects from it like I did before with a very dry mouth and gritting my teeth at night. Plaquenil and quinicrine not working anymore for lupus Plaquenil but no diagnosis Lupus Forums at The Lupus Site, What next if plaquenil doesn't work? What doctor can do plaquenil baseline testPlaquenil and pregnancy categoryWhere can i but the least expensive plaquenilCombination methotrexate and plaquenil It is not an alternative to Plaquenil for those reasons although it is sometimes used as a starter therapy in lupus for speedier effectiveness then changed to Plaquenil. I don't know why doctors who prescribe Plaquenil either for lupus or RA aren't willing to prescribe Quinacrine instead or in addition. Has anyone taken Quinacrine? -. Anxiety and Plaquenil Has anyone experienced mood. - LUPUS UK. Plaquenil and corona lupus. I have been on Quinacrine 100mgs a day for many years and have no perceptible yellowing. Retinal damage from Plaquenil is extremely rare when doses do not exceed the maximum recommended which is about 3 mgs per lb/ 6.5 mgs per kilo of IDEAL body weight and when the patient has no liver or kidney problems. Since doses are cumulative the risk. Lupus and Plaquenil research. While Plaquenil was not created with the explicit purpose of helping people minimize the disease activity of lupus, a number of clinical trials have been conducted to examine the clinical impact of the medication. This medicine is not effective against all strains of malaria. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Important information. Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye.