It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Chloroquine colon cancer Chloroquine and tlr signaling Plaquenil is available in generic form. What Are Side Effects of Plaquenil? Common side effects of Plaquenil include. nausea, vomiting, stomach pain or cramps, loss of appetite, weight loss, diarrhea, dizziness, spinning sensation, headache, ringing in your ears, mood changes, nervousness, irritability, skin rash, itching, or; hair loss. I got this after about 5 weeks, mine was a blistery rash and it was only on my shoulders, upper chest and upper back. My doctor said it was photodermatitis and caused from a sensitivity to the sun caused by the plaquenil. I had an itchy rash due to methotrexate. They thought it was most likely to be caused by Cimzia, so stopped both drugs, restarted MTX and the rash came back. So I had to stop that and started on new medication after the rash had subsided. The doctor hasn't seen that before, so it's not always the cause. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Rash after plaquenil Long-Term Side Effects of Plaquenil for Rheumatoid., Rash from plaquenil DailyStrength Eye doctor hydroxychloroquine That's a real common side effect of Lupus is unexplained rashes. If you've ever had an allergic reaction to a drug then this is the type of reaction you'd have if you were allergic to the Plaquenil; and they'd stay until the Plaquenil was out of your system. If they're coming and going more than likely it isn't the Plaquenil. Plaqunil rash -. Rash from Methotrexate or Hydroxychloroquine? - NRAS. Terrible Itching on Plaquenil---PLEASE HELP.. I broke out with a rash after being on it for a week. I was also on a mild muscle relaxer for about 3 weeks prior to plaquenil. I got off both then started back on plaquenil. No rash so I assumed it was the other med even though I was on it longer and before the plaquenil. Did not resume the other meds. I've been on prednisone for 5 months and then on plaquenil hydroxychloroquine and azathioprine for another 1month. Why my lupus rash is not going away after 6 months of rx? Hands broke out from generic plaquenil hydroxychloroquine. Was put on prednisone 5mg dr says he will ween me off pred. Put me on name brand plaquenil hydroxychloroquine. Aug 26, 2013 Plaquenil hydroxychloroquine Even though you dont have a rash Plaquenil hydroxychloroquine can be responsible for your itchy hands and feet. Consult your doctor for help. Consult your doctor for help.