I have been on plaquenil for about 10 weeks now without much success. I have had the sickness to my stomach and not felt like me including exhausted but it's not as bad as I feared. My hair is coming out slightly Not in clumps are anything, just a little here or there. My doctor said if I don't feel better in a few more weeks, we could switch my medicine. Really though in order not to have worse things happen it is what we have to do. I switched back to cymbalta three days ago and have experienced huge relief. Chloroquine resistant malaria treatment in children Treating psoriatic arthritis with plaquenil Compare Hydroxychloroquine vs Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Hydroxychloroquine rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction. What next if plaquenil doesn't work? Support Forums. I wish the plaquenil was working but it's not. I feel so bad every day. Prednisone ran my blood sugar up but I felt great on it, not that you want to take it for too long. mama6. Regular Member. Joined Jul 2010. I guess it helps me. I don't even know anymore. I have been on it for. What next if plaquenil doesn't work. I wish the plaquenil was working but it's not. I feel so bad every day. I don't even know anymore. I have been on it for. Vitamin B-12 might help with the hair, ask your doctor about that, well wishes to you and I hope the mtx can help you....((((((((((((((((((((((((((((((((((((((((((((((Jeanneac)))))))))))))))))))))))))))))))))))))))))healing hugz and well wishes and keep us posted on how your doing... Had headaches with the plaquenil so went to the sulfar and predisone. (like i did friday) Take care of yourself and big(((HUGS))) on your journey. He said it would be one that they would have to more closely monitor me on with some blood tests. I was thinking it was methotrexate but I do not want my hair to fall out. It might be coincidence but since on the plaquenil, I have noticed a growth spurt of hair especially at the hairline. Plaquenil made me sick, so I can't take it either, but there are other medicine out there,the doctor's will get you on something that'll help, keep hope..wishes to you and try the methotrexate,to see if it can help... I know it is scary but anything to stop the pain and misfunction of not being able to use my hands or move my knees or not have my ankles cave out and fall. I suspected that I had fibromyalgia on top of the inflammation. I am so relieved but hope I don't start having bad side effects from it like I did before with a very dry mouth and gritting my teeth at night. Plaquenil and quinacrine not working anymore for lupus Treating Lupus With Antimalarial Drugs Woodland Hills Pharmacy, What next if plaquenil doesn't work? Signs that plaquenil is eye damagePlaquenil storage water or fat solubleLupus medications aralenPlaquenil side effects skin These drugs may take one to three months to make a noticeable difference in your lupus symptoms. You may need to take extra steroids to improve your symptoms until the antimalarials begin to work. When lupus becomes more severe, antimalarials may not be enough to prevent complications in the kidneys, nervous system, or cardiovascular system. Antimalarials. What next if plaquenil doesn't work? -. Quinacrine/atabrine alternative to plaquenil. I was on quinacrine in addition to plaquenil for a bit, and my doctor added this because I was still exhibiting a significant amount of disease activity that the plaquenil alone was not suppressing. But my lupus has never been severe, compared to some of what others in this sub have experienced. It has numerous benefits on lupus and in general tends to lower cholesterol for instance. It is interesting that you were first prescribed mepacrine/quinacrine instead of Plaquenil. Mepacrine will do more to battle the fatigue as it is stimulating, Plaquenil is not as helpful in that respect as it is not stimulating. Today’s AMs are hydroxychloroquine Plaquenil®, chloroquine Aralen®, and quinacrine Atabrine®. Quinacrine is no longer marketed in the U. S.; it can be dispensed by a compounding pharmacy, although insurance companies may not pay for it. The antimalarial quinine was first used to treat cutaneous lupus in 1834.