I don't get many side effects generally, but with prednisone I DO. It does help, but this can't be a long term affair. Plaquenil is a great drug (I have no experience with it, but many people with lupus take it). I'd ask your rheumy about it and have them explain why they made that choice for you. Prednisone is an intermediate acting corticosteroid-which means it has direct anti-inflamitory properties that take effect begining in a few hours. Is plaquenil another option instead of the prednisone? It is ment to get this undercontrol now and diminish your pain. Plaquenil lichen sclerosus Drug interaction of chloroquine Plaquenil increased fatigue When my wife was first diagnosed with PMR in May, 2016, she was put on 15mg Pred. A month later, she was told to take 400mg of plaquenil daily, with the understanding that plaquenil would replace prednisone eventually. This rheumy tried to get her down to 5mg six months later, which was a total mistake. Drugs & Medications Plaquenil. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. It has not direct anti-inflamitory properties and instead works on the immune system-though the mechanism is not known. Plaq is a longer time medication it may take two months before their is a noticable difference. What time should i take my prednisone and my plaquenil I'm using plaquenil hydroxychloroquine 200mg and., Plaquenil Oral Interactions with Other Medication Can hydroxychloroquine 200 mg get you highMalarone chloroquine resistancePlaquenil canadaHydroxychloroquine sulfate and prednisone together Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Take this drug at the times recommended by. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Plaquenil vs. Prednisone Prescription Treatment for.. Plaquenil vs Prednisone Comparison -. My body was crashing hard with no sleep or food and basically a total water diet. I feel the dosage was way too high for someone my size, and with never taking it before, I regret it. I will never again take this pill for anything. At this point, my body hurts so bad; as if I’ve been taking it for a long period of time. The prednisone is a steriod and the plaquenil is a anti malaria drug. The thing with plaquenil for me is that I don't notice much of anything taking it but when I go off then I flare up and then really notice it. I have been taking the plaquinil for about 8 years morning and night and the prednisone off and on. Summary Drug interactions are reported among people who take Prednisone and Plaquenil together. This study is created by eHealthMe based on reports of 13,794 people who take Prednisone and Plaquenil from Food and Drug Administration FDA, and is updated regularly.