Mechanism of chloroquine on lysosome

Discussion in 'Aralen' started by mr. Prof, 19-Mar-2020.

  1. DOKTORVAMPIR Guest

    Mechanism of chloroquine on lysosome


    Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. This medication is used to kill the malaria parasites living inside red blood cells.

    Hydroxychloroquine and edema Mechanism of action hydroxychloroquine Hydroxychloroquine sulfate eye side effects

    The consortium aims at elucidating the molecular mechanisms of maintaining lysosomal homeostasis and the adaptive regulatory mechanisms to compensate lysosomal dysfunctions. The FOR2625 research program strongly benefits from the wide spread expertises of its members by synergistic collaborations and focusses on three key objectives Chloroquine Phosphate. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Sep 15, 2013 Accumulation of chloroquine in the lysosome inhibits phospholipase A2. It has recently been shown that antagonists of cytoplasmic phospholipase A2 inhibit multiple endocytic pathways 42. In this case, chloroquine could be maintaining BMPR-II at the cell surface via another mechanism other than lysosomal inhibition.

    Both drugs may be needed for a complete cure and to prevent the return of infection (relapse). In some cases, you may need to take a different medication (such as primaquine) to kill the malaria parasites living in other body tissues.

    Mechanism of chloroquine on lysosome

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  3. Hydroxychloroquine and chloroquine are antimalarial drugs commonly used for the treatment of rheumatic diseases.

    • Mechanisms of action of hydroxychloroquine and chloroquine..
    • The lysosomal inhibitor, chloroquine, increases cell surface..
    • Mechanisms of drug action and resistance.

    Chloroquine enters the red blood cell, inhibiting the parasite cell and digestive vacuole by simple diffusion. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. This leads to an irreversible accumulation of chloroquine in lysosomes to 100-fold excess concentration and causes an elevation of pH due to trapping of H + ions by chloroquine. 87 Hydroxychloroquine, a related lysosomotropic amine, appears to be very similar to chloroquine in its effect on cellular function. Thus, chloroquine analogues. Autophagy 2018-6-27 Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. Mario Mauthe, Idil Orhon, Cecilia Rocchi, Xingdong Zhou, Morten Luhr, Kerst-Jan Hijlkema, Robert P Coppes, Nikolai Engedal, Muriel Mari, Fulvio Reggiori

     
  4. pashgen Well-Known Member

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  5. ShiSha_34 Well-Known Member

    Hydroxychloroquine overcomes tamoxifen resistance in. Since chloroquine is an 'old' drug, repurposing it to help breast cancer patients should also be very cost effective." Hydroxychloroquine inhibits autophagy, a prosurvival process that breast cancer cells induce and that antiestrogens can stimulate. Whether interfering with this process can enhance breast cancer therapy remains unknown.

    Chloroquine in Cancer Therapy A Double-Edged Sword of.
     
  6. BSnew Moderator

    MANAGEMENT OF DIFFICULT URTICARIA Dapsone, colchicine, hydroxychloroquine, oral tacrolimus, cyclophosphamide, and low dose methotrexate, which have immunomodulatory properties, are effective in the treatment of chronic urticaria.24,33,43–45

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