Now a paper published January 17 in the journal describes a new drug combination that has stabilized Rosendahl's disease and increased both the quantity and quality of her life: Adding the anti-malaria drug chloroquine to her treatment stopped an essential process that Rosendahl's cancer cells had been using to resist therapy, re-sensitizing her cancer to the targeted treatment that had previously stopped working. Along with Rosendahl, two other brain cancer patients were treated with the combination and both showed similar, dramatic improvement. Compare sulfasalazine to plaquenil Aralen phosphate cost There is a growing evidence that antimalarial chloroquine could be re-purposed for cancer treatment. A dozen of clinical trials have been initiated within the past 10 years to test the potential of chloroquine as an adjuvant treatment for therapy–refractory cancers including glioblastoma, one of the most aggressive human cancers. Chloroquine and Sulfadoxine – Pyrimethamine, the first line drugs in the treatment of malaria, banned by the Federal Government in 2005 because of increasing evidence of drug resistance, which had led to treatment failures, has being found to be used for treatment of cancer. The science behind the innovative, off-label use of this malaria drug, chloroquine, was in large part built in the lab of Andrew Thorburn, PhD, deputy director of the CU Cancer Center, where Mulcahy-Levy worked as a postdoctoral fellow, starting in 2009. Thorburn's lab studies a cellular process called autophagy. They tested it for cancer and it came back positive," Lisa says. "When I was 21 they found a large mass in my brain and I had it resected right away. Chloroquine brain tumor This Malaria Drug Is Having an Amazing Effect on Brain., Malaria drug, chloroquine, treats brain cancer New Mail Nigeria Plaquenil angerPlaquenil labs The i.v. injection of chloroquine during intracerebral infusion of Tf-CRM107 may protect the vasculature, permitting less toxicity to the brain while allowing greater doses of Tf-CRM107 to be delivered to tumor to further improve the response rate of this new cancer therapy. Vascular Protection by Chloroquine during Brain Tumor Therapy.. Malaria drug successfully treats 26-year-old brain cancer.. Our brain tumor cocktails and stories Inhibitors of autophagy. Glioblastoma multiforme GBM is the most aggressive brain tumor. Despite its high degree of hypoxia, it can survive and resist anticancer treatments. Thus, it is important to study the main GBM adaptive strategies. Autophagy is a catabolic process that can be induced by hypoxia. This medicine may add to the chance of getting some types of cancer. Talk with the doctor. Keep away from children. Accidental exposure may cause death. If a child takes chloroquine by accident, get medical help right away. If you are 65 or older, use chloroquine with care. You could have more side effects. In a small number of patients with brain tumors, the team found that adding the autophagy inhibitor chloroquine after failure of the BRAFV600E inhibitor vemurafenib, it is possible to overcome kinase inhibitor resistance. The investigators have demonstrated.